Translational Cardiorespiratory Research Lab

Publications

Here is just a selection of our latest publications. Please search Pubmed for a complete list.

Forgotten Circulation: Reduced Mesenteric Venous Capacitance in Hypertensive Rats Is Improved by Decreasing Sympathetic Activity.

Emans TW, Moraes DJA, Ben-Tal A, Barrett CJ, Paton JFR, McBryde FD. Hypertension. 2024 Feb 21. doi: 10.1161/HYPERTENSIONAHA.123.21878. PMID: 38380519

Carotid body dysregulation contributes to Long COVID symptoms.

El-Medany A, Adams ZH, Blythe HC, Hope KA, Kendrick AH, Abdala Sheikh AP, Paton JFR, Nightingale AK, Hart EC. Commun Med (Lond). 2024 Feb 19;4(1):20. doi: 10.1038/s43856-024-00447-5.PMID: 38374172

Chronic intermittent hypoxia remodels catecholaminergic nerve innervation in mouse atria.

Bizanti A, Zhang Y, Toledo Z, Bendowski KT, Harden SW, Mistareehi A, Chen J, Gozal D, Heal M, Christie R, Hunter PJ, Paton JFR, Cheng ZJ. J Physiol. 2024 Jan;602(1):49-71. doi: 10.1113/JP284961. PMID: 38156943

Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease.

Lataro RM, Brognara F, Iturriaga R, Paton JFR. Auton Neurosci. 2024 Feb;251:103137. doi: 10.1016/j.autneu.2023.103137. PMID: 38104365 Review.

Acute poisoning by chlorpyrifos differentially impacts survival and cardiorespiratory function in normotensive and hypertensive rats.

Aitken AV, Minassa VS, Batista TJ, Oliveira JKDS, Sant’Anna KO, Felippe ISA, Paton JFR, Coitinho JB, Bissoli NS, Sampaio KN. Chem Biol Interact. 2024 Jan 5;387:110821. doi: 10.1016/j.cbi.2023.110821. PMID: 38042398

Commonalities and differences in carotid body dysfunction in hypertension and heart failure.

Felippe ISA, Río RD, Schultz H, Machado BH, Paton JFR. J Physiol. 2023 Dec;601(24):5527-5551. doi: 10.1113/JP284114. PMID: 37747109

The skeletal muscle metaboreflex: a novel driver of ventilation, dyspnoea and pulmonary haemodynamics during exercise in pulmonary arterial hypertension.

Plunkett MJ, Sayegh ALC, McWilliams TJ, Sithamparanathan S, Paton JFR, Fisher JP. Eur Respir J. 2024 Jan 4;63(1):2300952. doi: 10.1183/13993003.00952-2023. PMID: 37678950

Ventilatory Efficiency Is Reduced in People With Hypertension During Exercise.

Hope K, Chant B, Hinton T, Kendrick AH, Nightingale AK, Paton JFR, Hart EC. J Am Heart Assoc. 2023 Jul 4;12(13):e024335. doi: 10.1161/JAHA.121.024335. PMID: 37345800

Transcriptomics of the Carotid Body.

Pauza AG, Murphy D, Paton JFR. Adv Exp Med Biol. 2023;1427:1-11. doi: 10.1007/978-3-031-32371-3_1.PMID: 37322330 Review.

Venous capacity and compliance in hypertensive adults: influence of hypoxia and hyperoxia.

Fan JL, Sayegh ALC, Babbage T, Dawes M, Paton JFR, Fisher JP. J Appl Physiol (1985). 2023 Jun 1;134(6):1409-1421. doi: 10.1152/japplphysiol.00670.2022. PMID: 37078505

Central and peripheral chemoreflexes in humans with treated hypertension.

Sayegh ALC, Fan JL, Dawes M, Paton JFR, Fisher JP. J Physiol. 2023 Jun;601(12):2425-2445. doi: 10.1113/JP284249. PMID: 37014129

Carotid body: an emerging target for cardiometabolic co-morbidities.

Thakkar P, Pauza AG, Murphy D, Paton JFR. Exp Physiol. 2023 May;108(5):661-671. doi: 10.1113/EP090090. PMID: 36999224 Review.

P2X3 receptor antagonism attenuates the progression of heart failure.

Lataro RM, Moraes DJA, Gava FN, Omoto ACM, Silva CAA, Brognara F, Alflen L, Brazão V, Colato RP, do Prado JC Jr, Ford AP, Salgado HC, Paton JFR. Nat Commun. 2023 Mar 28;14(1):1725. doi: 10.1038/s41467-023-37077-9.PMID: 36977675

Intermittent exposure to chlorpyrifos results in cardiac hypertrophy and oxidative stress in rats.

Minassa VS, Aitken AV, Hott SC, de Sousa GJ, Batista TJ, Gonçalves RCR, Coitinho JB, Paton JFR, Beijamini V, Bissoli NS, Sampaio KN. Toxicology. 2022 Dec;482:153357. doi: 10.1016/j.tox.2022.153357. PMID: 36341877

Cellular basis of learning and memory in the carotid body.

Gold OMS, Bardsley EN, Ponnampalam AP, Pauza AG, Paton JFR. Front Synaptic Neurosci. 2022 Aug 15;14:902319. doi: 10.3389/fnsyn.2022.902319. eCollection 2022. PMID: 36046221 Review.

Respiratory-cardiovascular interactions.

Fisher JP, Zera T, Paton JFR. Handb Clin Neurol. 2022;188:279-308. doi: 10.1016/B978-0-323-91534-2.00006-0. PMID: 35965029 Review.

Peripheral chemoreflex activation induces expiratory but not inspiratory excitation of C1 pre-sympathetic neurones of rats.

da Silva MP, Spiller PF, Paton JFR, Moraes DJA. Acta Physiol (Oxf). 2022 Aug;235(4):e13853. doi: 10.1111/apha.13853. PMID: 35722749

Examination of the periaqueductal gray as a site for controlling arterial pressure in the conscious spontaneously hypertensive rat.

O’Callaghan EL, McBryde FD, Patel NK, Paton JFR. Auton Neurosci. 2022 Jul;240:102984. doi: 10.1016/j.autneu.2022.102984. PMID: 35526354

Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation.

Sayegh ALC, Fan JL, Vianna LC, Dawes M, Paton JFR, Fisher JP. J Physiol. 2022 Jun;600(11):2669-2689. doi: 10.1113/JP282327. PMID: 35482235 Clinical Trial.